Entrée Capital new investment vehicle aims to accelerate early-stage Web3 infrastructure, autonomous AI systems and decentralized physical networks.
Entrée Capital has introduced a $300 million fund dedicated to early-stage crypto and Web3 infrastructure, highlighting the growing institutional appetite for blockchain systems that plug seamlessly into modern technology environments.
The fund will invest from pre-seed through Series A, backing teams developing the foundational layers required for large-scale Web3 adoption. Its focus areas include AI agents capable of autonomously managing digital assets under cryptographic policy frameworks, as well as DePIN networks, which leverage token incentives to coordinate, finance and operate real-world physical infrastructure.
The firm emphasized that its long-standing experience across fintech and crypto — including early investments in Stripe, Rapyd, Mesh, and Web3 pioneers such as Gen Labs and Breez — positions it to support founders operating at the intersection of regulated finance and decentralized protocols.
A fund built to support next-generation Web3 foundations
Institutional investors are increasingly drawn to AI agents and DePIN because they represent crypto-native extensions of two of today’s fastest-growing technology pillars: artificial intelligence and cloud computing. AI agents introduce the possibility of fully autonomous asset management governed by secure cryptographic rules, while DePIN networks expand the cloud model by enabling community-powered infrastructure deployment.
Together, these sectors provide a pathway toward secure, automated and highly scalable systems capable of delivering both digital and physical utility. For institutions, this translates into access to next-generation infrastructure aligned with evolving demands in finance, logistics, computing and automation.
With its new fund, Entrée Capital aims to play a central role in supporting the builders shaping the next wave of decentralized technology and AI-driven infrastructure.
